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KMID : 1144220230290030092
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Journal of Menopausal Medicine
2023 Volume.29 No. 3 p.92 ~ p.96
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Tibolone and Breast Cancer
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Lee Jae-Kyung
Yun Hye-Won
Kim Hee-Yon
Yun Bo-Hyon
Seo Seok-Kyo
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Abstract
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Tibolone, a selective tissue estrogenic activity regulator, is a synthetic steroid with distinct pharmacological and clinical characteristics in contrast to conventional menopausal hormone therapy. Tibolone induces estrogenic activity in the brain, vagina, and bone but remains inactive in the endometrium and breast. In particular, several studies have investigated whether tibolone usage increases the risk of breast cancer. This study aims to determine the effects of tibolone on the breast by focusing on the relation between tibolone use and breast cancer. Our investigation emphasizes recent studies, particularly those based on Asian populations.
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KEYWORD
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Breast density, Breast neoplasms, Postmenopausal hormone replacement therapy, Tibolone
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